Syntegon Launches Sepion 75 Tablet Coater

Syntegon, a strategic lifecycle partner to the pharmaceutical and biotech industry has expanded its Oral Solid Dosage (OSD) processing portfolio with the Sepion 75. The new pilot-scale tablet coater is designed to support manufacturers and CDMOs in handling growing product diversity, smaller and more variable batch sizes, and stricter containment requirements for highly potent active ingredients.

The new coater completes the established Sepion series and supports consistent scale-up, faster flexible batch processing, and containment-oriented manufacturing.

Building on decades of coating expertise, the Sepion series combines established process knowledge with a machine concept tailored to modern pharmaceutical manufacturing requirements. Apart from the Sepion 75, the coater series is available in six sizes variants from 175 to 1,000 liters capacity, covering scalable production outputs from development to commercial manufacturing.

“By extending the Sepion series to the pilot scale, we support pharmaceutical manufacturers in simplifying development and scale-up while maintaining consistent process principles across production stages,” says Fritz-Martin Scholz, Global Product Manager at Syntegon.

Flexible Batch Processing for Changing Production Needs

The Sepion 75 supports flexible pilot-scale batch processing across 10 to 100 percent of its maximum working volume. Two interchangeable drums cover 8 to 75 liters, enabling early development and advanced pilot runs on one machine without redefining process parameters, while helping reduce changeover downtime.

Optimized drum geometry, an advanced spraying system, and an automatically adjustable spray arm improve air usage, shorten processing times, and maintain reproducible coating conditions across batch sizes, including demanding functional coating applications.